Hmmm, that's kind of a loaded question because it really depends on what the artist does with their influences as I don't think anyone can really be all that non-derivative anymore. I'll pick three albums that came out in the 2000s that strike me as a sound that was very fresh to me and I think also very influential.

The Dirty Three - Whatever You Love, You Are
The Notwist - Neon Golden
Godspeed You Black Emperor! - Lift Your Skinny Fists Like Antennas to Heaven

That previous Solex album Low Kick And Hard Bop from 2001 was another that knocked me for a loop as does the Fiery Furnaces new one. Calexico has been putting out some pretty unique sounding albums. Yume Bitsu is pretty unique. Kinski integrates their influences into a fairly unique sound. Lots more come to mind as well. I think it still fairly easy to be unique even today, just don't quite know about the non-derivative part