Like Dave G, it's no contest for me. Talking Heads all the way.

Altho I like Radiohead more than Dave (well, "The Bends" and "OK Computer" anyway) it's really a question of innovation and attitude.

The Heads were constantly bringing new things to the table. They did so many things first. OTOH, contrary to popular belief, Radiohead really hasn't done anything that hasn't already been done before.

Talking Heads are fun. They have a somewhat comedic and tongue in cheek nature. Radiohead is somber and depressing. They are decidedly NOT fun.

I also don't care for Radiohead's production values. All their albums (to varying degrees) sound dirty, brittle and compressed to death. I realize that they are doing it on purpose to create atmosphere, but to me it's cheap and lazy way of doing it.