Get a group of approximately 8 to 10 people to encircle your speakers. Put in a nature CD with some ocean sounds, turn down the lights, turn on a strobe light, have everyone hold hands without any clothing to eliminate any chance of static buildup, and start chanting artifacts be gone over and over until the sound of the ocean waves feel like they are sweeping over your bare feet. Sometimes just calling the local witch-doctor to do his own dance seems to work as well.

Seriously, I have a CD by Sheffield Labs containing a break-in track that I put on repeat for a number of days. It supposedly speeds up the break-in process. Basically it plays either white or pink noise while simultaneously playing a repeating low to high frequency.