I would venture to say the most popular UM here is the Harmony 880. I went from a Sony RM3000 to the 880 and it was a quantum leap in user friendliness. All functions are downloadable online and the user interface is as simple as they come. Highly recommended.

If you'd like a little more research, check out remotecentral.com. The forums there are also a good place to check out potential shortcomings with whatever you choose.

Hope this helps.