Given a HUGE budget, (about $8000), I think I'd go once again to D3: Computer => DAC/preamp => Active speakers.

In this case no fooling around with half-measures:

DAC/preamp/digital equalizer: Lyngdorf DPA-1, HERE ...




Active speakers: Genelec 8030.LSE Triple Play system, two 8030A monitors + 7050B subwoofer, HERE ...