There have been alot of movies made with big truck as the main theme, and IMO these are some of the better ones.

Not in any particulare order:

Sorcerer (1977): Roy Scheider carry nitroglycerin through miles of treasurous South America jungle in ancient trucks.


Smokey and the Bandit (1977): The Bandit is hired to run a tractor trailer full of beer over county lines in hot pursuit by a pesky sheriff.


Road Worrier (1981): The last scene with the tanker truck is probably the best chase scene in movie history.


Duel (1971): TV movie that put Steven Spielberg on the map. With Dennis Weaver.


Convoy (1978): Kris Kristofferson lead a truck convoy heading for Mexico. With Earnest Borgnine.