Best Villain Hero Combo

Which of these classic Villain Hero Dustups is the best. Who do you like to see go toe to toe and why. Enquring minds wanna know. Many long term grudges like Roadrunner vs. Coyote and Buggs vs. Daffy were left out as they were too one sided and simplistic. Hammer vs. Nail is NOT a grudge match as the nail never wins. At least Tom and Fudd get some licks in sometimes before going down in flames.

Da Worfster

I've always been a sucker for the epic battle of wits. Moriarty as Puppet Master of the London underworld is the perfect nemesis for Doyle's almost other-worldly problem solving detective. I don't now how many times, during the course of the series, that Holmes and Moriarty faced off, but each of these meetings became the most memorable parts (IMO) of the story.